Published Research from MetroHealth Cardiologists and Vascular Surgeons

Research is part of the culture at MetroHealth. Every day, our cardiologists and vascular surgeons perform vital research into the mechanisms of disease and disease management, and share those results with the international medical community through published studies.

• Pasala T., Dettmer M., Leo P., Laurita K., Kaufman E. "Microvolt T-Wave Alternans Amplifies Spatial Dispersion of Repolarization in Human Subjects With Ischemic Cardiomyopathy." J Electrocardiol. 2016 Jun 9. pii: S0022-0736(16)30067-X. doi: 10.1016/j.jelectrocard.2016.06.002.
• Zhang C., Kutyifa V., Moss A., McNitt S., Zareba W., Kaufman E. "Long-QT Syndrome and Therapy for Attention Deficit/Hyperactivity Disorder." J Cardiovasc Electrophysiol. 2015 Oct;26(10):1039-44. doi: 10.1111/jce.12739. Epub 2015 Aug 6.
• Cutler M., Kaufman E. "To Be or Not to Be: Long-QT Syndrome Type 9." Circ Cardiovasc Genet. 2013 Oct;6(5):439-40. doi: 10.1161/CIRCGENETICS.113.000345.
• Kaufman E. "Mutation Location Matters in Long QT Syndrome Type 2 (but Behavior Matters More)." Heart Rhythm. 2013 Jan;10(1):68-9. doi: 10.1016/j.hrthm.2012.10.004. Epub 2012 Oct 4.
• Kaufman E., Lewis S., Leo P., Aswath G., Ziv O., Fendelander L."Microvolt-Level T-Wave Alternans Determination Using the Spectral Method in Patients With QT Prolongation: Value of Adjusting the T-wave Window." J Electrocardiol. 2012 Nov-Dec;45(6):758-63. doi: 10.1016/j.jelectrocard.2012.07.007. Epub 2012 Sep 7.
• Kaufman E. "Genetic Testing in Brugada Syndrome." J Am Coll Cardiol. 2012 Oct 9;60(15):1419-20. doi: 10.1016/j.jacc.2012.05.011. Epub 2012 Jul 25. No abstract available.
• Murad K., Dunlap M. "Measuring Congestion in Acute Heart Failure: The 'Holy Grail' Still Awaits." J Card Fail. 2016 Jul 1. pii: S1071-9164(16)30549-8. doi: 10.1016/j.cardfail.2016.06.424. [Epub ahead of print]
• Dunlap M., Bhardwaj A., Hauptman P. "Autonomic Modulation in Heart Failure: Ready for Prime Time?" Curr Cardiol Rep. 2015 Nov;17(11):103. doi: 10.1007/s11886-015-0652-2. Review.
• Bhardwaj A., Dunlap M. "Autonomic Dysregulation as a Therapeutic Target for Acute HF." Curr Treat Options Cardiovasc Med. 2015 Oct;17(10):403. doi: 10.1007/s11936-015-0403-0.
• Jouett N., Watenpaugh D., Dunlap M., Smith M. "Interactive Effects of Hypoxia, Hypercapnia and Lung Volume on Sympathetic Nerve Activity in Humans." Exp Physiol. 2015 Sep;100(9):1018-29. doi: 10.1113/EP085092. Epub 2015 Aug 11.
• Crissinger M., Marchionda K., Dunlap M. "Adherence to Clinical Guidelines in Heart Failure (HF) Outpatients: Impact of an Interprofessional HF Team on Evidence-Based Medication Use." J Interprof Care. 2015;29(5):483-7. doi: 10.3109/13561820.2015.1027334. Epub 2015 Jun 19.
• Vallakati A., Sharma A., Madmani M., Reddy M., Kanmanthareddy A., Gunda S., Lakkireddy D., Lewis W. "Efficacy and Safety of Novel Oral Anticoagulants for Atrial Fibrillation Ablation: An Updated Meta-Analysis." Cardiol Ther. 2016 Jun;5(1):85-100. doi: 10.1007/s40119-016-0061-7. Epub 2016 Apr 22.
• Vallakati A., Lewis W. "Underuse of Anticoagulation in Patients With Atrial Fibrillation." Postgrad Med. 2016;128(2):191-200. doi: 10.1080/00325481.2016.1132939. Epub 2016 Jan 8. Review.
• Lewis W., Piccini J., Turakhia M., Curtis A., Fang M., Suter R., Page RL 2nd, Fonarow G. "Get With The Guidelines AFIB: Novel Quality Improvement Registry for Hospitalized Patients With Atrial Fibrillation." Circ Cardiovasc Qual Outcomes. 2014 Sep;7(5):770-7. doi: 10.1161/CIRCOUTCOMES.114.001263. Epub 2014 Sep 2.
• Lewis W., Fonarow G., Grau-Sepulveda M., Smith E., Bhatt D., Hernandez A., Olson D., Peterson E., Schwamm L. "Improvement in Use of Anticoagulation Therapy in Patients with Ischemic Stroke: Results From Get With The Guidelines-Stroke." Am Heart J. 2011 Oct;162(4):692-699.e2. doi: 10.1016/j.ahj.2011.07.019. Epub 2011 Sep 15.
• Bhat P., Khan I., Finkelhor R., Bahler R., Rovner A. "Right Ventricular Myocardial Performance Index Derived From Tissue Doppler Echocardiography Is Useful in Differentiating Apical Ballooning Syndrome From Cardiomyopathy Due to Left Anterior Descending Coronary Artery Disease" J Am Soc Echocardiogr. 2014 Jan;27(1):101-6. doi: 10.1016/j.echo.2013.09.001. Epub 2013 Oct 9.
• Finkelhor R., Scrocco J., Madmani M., Rovner A., Pillai D. "Discordant Doppler Right Heart Catheterization Pulmonary Artery Systolic Pressures: Importance of Pulmonary Capillary Wedge Pressure." Echocardiography. 2014 Mar;31(3):279-84. doi: 10.1111/echo.12361. Epub 2013 Sep 13.
• Finkelhor R., Lewis S., Pillai D. "Limitations and Strengths of Doppler/Echo Pulmonary Artery Systolic Pressure-Right Heart Catheterization Correlations: a Systematic Literature Review." Echocardiography. 2015 Jan;32(1):10-8. doi: 10.1111/echo.12594. Epub 2014 Mar 25. Review.
• Nemeth A., Bahler R., Finkelhor R. "The Diagnostic Utility of Heart Rate-Corrected ST-Segment Depression During Adenosine Nuclear Stress Testing." J Electrocardiol. 2010 May-Jun;43(3):237-41. doi: 10.1016/j.jelectrocard.2009.12.003. Epub 2010 Jan 8.
• Sandhu R., Finkelhor R., Gunawardena D., Bahler R. "Prevalence and Characteristics of Left Ventricular Noncompaction in a Community Hospital Cohort of Patients With Systolic Dysfunction." Echocardiography. 2008 Jan;25(1):8-12. doi: 10.1111/j.1540-8175.2007.00560.x.
• Hanna M., Finkelhor R., Shaw W., Bahler R. "Extent of Right and Left Ventricular Focal Wall-Motion Abnormalities in Differentiating Transient Apical Ballooning Syndrome From Apical Dysfunction as a Result of Coronary Artery Disease." J Am Soc Echocardiogr. 2007 Feb;20(2):144-50.
• Bahler R., Mohyuddin T., Finkelhor R., Jacobs I. "Contribution of Doppler Tissue Imaging and Myocardial Performance Index to Assessment of Left Ventricular Function in Patients with Duchenne's Muscular Dystrophy." J Am Soc Echocardiogr. 2005 Jun;18(6):666-73.
• Aneja A. "How to Distinguish Between Myocarditis and Sarcoidosis Based on CMR Imaging." JACC Cardiovasc Imaging. 2016 Mar;9(3):327. doi: 10.1016/j.jcmg.2015.05.015. No abstract available.
• Pattanshetty D., Bhat P., Gandhi S., Pillai D., Aneja A. "Comparing Stress Testing and Fractional Flow Reserve to Evaluate Presence, Location and Extent of Ischemia in Coronary Artery Disease." Indian Heart J. 2015 Jan-Feb;67(1):50-5. doi: 10.1016/j.ihj.2015.02.010. Epub 2015 Feb 25.
• Pattanshetty D., Bhat P., Aneja A., Pillai D. "Elevated Troponin Predicts Long-Term Adverse Cardiovascular Outcomes in Hypertensive Crisis: A Retrospective Study." J Hypertens. 2012 Dec;30(12):2410-5. doi: 10.1097/HJH.0b013e3283599b4f.
• Fallick C., Sobotka P., Dunlap M. "Sympathetically Mediated Changes in Capacitance: Redistribution of the Venous Reservoir as a Cause of Decompensation." Circ Heart Fail. 2011 Sep;4(5):669-75. doi: 10.1161/CIRCHEARTFAILURE.111.961789.
• Rizik D., Klassen K., Burke R., Hodgson J., Stone G. "Interventional Management of Unprotected Left Main Coronary Artery Disease: Patient Selection and Technique Optimization." J Interv Cardiol. 2015 Aug;28(4):326-38. doi: 10.1111/joic.12211. Epub 2015 Jun 16. Review.
• Hodgson J. "What Part of the FFR Link Don't We Understand?" J Am Coll Cardiol. 2014 Oct 21;64(16):1655-7. doi: 10.1016/j.jacc.2014.08.011.
• Taylor A., Cerqueira M., Hodgson J., Mark D., Min J., O'Gara P., Rubin G. "ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance." J Cardiovasc Coput Tomogr. 2010 Nov-Dec;4(6):407.e1-33. doi: 10.1016/j.jcct.2010.11.001. Epub 2010 Nov 23.
• Blankenship J., Scott T., Skelding K., Haldis T., Tompkins-Weber K., Sledgen M., Donegan M., Buckley J., Sartorius J., Hodgson J., Berger P. "Door-to-Balloon Times Under 90 Min Can Be Routinely Achieved for Patients Transferred for ST-Segment Elevation Myocardial Infarction Percutaneous Coronary Intervention in a Rural Setting." J Am Coll Cardiol. 2011 Jan 18;57(3):272-9. doi: 10.1016/j.jacc.2010.06.056.
• Greenland P., Alpert J., Beller G., Benjamin E., Budoff M., Fayad Z., Foster E., Hlatky M., Hodgson J., Kushner F., Lauer M., Shaw L., Smith S., Taylor A., Weintraub W., Wenger N., Jacobs A., Smith S., Anderson J., Albert N., Buller C., Creager M., Ettinger S., Guyton R., Halperin J., Hochman J., Kushner F., Nishimura R., Ohman E., Page R., Stevenson W., Tarkington L., Yancy C; American College of Cardiology Foundation; American Heart Association. "2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines." J Am Coll Cardiol. 2010 Dec 14;56(25):e50-103. doi: 10.1016/j.jacc.2010.09.001.
• Cutler M., Johnson J., Abozguia K., Rowan S., Lewis W., Costantini O., Natale A., Ziv O. "Impact of Voltage Mapping to Guide Whether to Perform Ablation of the Posterior Wall in Patients With Persistent Atrial Fibrillation." J Cardiovasc Electrophysiol. 2016 Jan;27(1):13-21. doi: 10.1111/jce.12830. Epub 2015 Oct 30.
• Kim T., Kunitomo Y., Pfeiffer Z., Patel D., Hwang J., Harrison K., Patel B., Jeng P., Ziv O., Lu Y., Peng X., Qu Z., Koren G., Choi B. "Complex Excitation Dynamics Underlie Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Syndrome Type 1." Heart Rhythm. 2015 Jan;12(1):220-8. doi: 10.1016/j.hrthm.2014.10.003. Epub 2014 Oct 5.
• Sattayaprasert P., Nassal D., Wan X., Deschenes I., Laurita K. "Mesenchymal Stem Cells Suppress Cardiac Alternans by Activation of PI3K Mediated Nitroso-Redox Pathway." J Mol Cell Cardiol. 2016 Sep;26;98:138-145. doi: 10.1016/j.yjmcc.2016.05.014. Epub 2016 May 26.
• Nassal M., Werdich A., Wan X., Hoshi M., Deschênes I., Rosenbaum D., Donahue J. "Phosphorylation at Connexin43 Serine-368 Is Necessary for Myocardial Conduction During Metabolic Stress." J Cardiovasc Electrophysiol. 2016 Jan;27(1):110-9. doi: 10.1111/jce.12833. Epub 2015 Oct 13.
• Plummer B., Liu H., Wan X., Deschênes I., Laurita K. "Targeted Antioxidant Treatment Decreases Cardiac Alternans Associated With Chronic Myocardial Infarction." Circ Arrhythm Electrophysiol. 2015 Feb;8(1):165-73. doi: 10.1161/CIRCEP.114.001789. Epub 2014 Dec 9.
• Hoshi M., Du X., Shinlapawittayatorn K., Liu H., Chai S., Wan X., Ficker E., Deschênes I. "Brugada Syndrome Disease Phenotype Explained in Apparently Benign Sodium Channel Mutations." Circ Cardiovasc Genet. 2014 Apr;7(2):123-31. doi: 10.1161/CIRCGENETICS.113.000292. Epub 2014 Feb 26.
• Nassal D., Wan X., Liu H., Deschênes I. "Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role." PLoS One. 2016 Jan 14;11(1):e0146561. doi: 10.1371/journal.pone.0146561. eCollection 2016.