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Hand and Upper Extremity Research

Current Studies

Bibliographic body of published work by MetroHealth hand and upper extremity experts.

A Clinical Trial for the Surgical Treatment of Distal Radius Fracture in the Elderly: Wrist and Radius Injury Surgical Trial

WRIST is an international multi-centered prospective randomized study designed to identify the most appropriate treatment for wrist fractures in the osteoporotic elderly patient. Fragility fractures of the wrist are an increasingly common occurrence and there have been many proposed treatments for these injuries which can result in significant morbidity and impact on patient function and independence. This study could provide powerful information on how to advise and treat these patients regarding their injuries.

Principal Investigator: Kevin J. Malone, MD

Completed Studies

Multi-Center Prospective Study of the Treatment for Brachial Palsy

Brachial plexus birth palsy (BPBP) refers to the paralysis of the upper extremity caused by a traction injury of the brachial plexus during birth. BPBP may vary in severity ranging from temporary stretching of the brachial plexus nerves to complete cervical nerve root separation from the spinal cord of part or all of the brachial plexus nerve. This study is a formal protocol of evaluation and treatment, this study may provide for a more organized and thorough means for following and treating infants with this disorder. The information collected from this study will help to further our understanding of the treatment of BPBP and provide more objective data to guide both physicians and families.

Principal Investigator: Harry Hoyen, MD
Co-Investigator: Michael Keith, MD



Overviews of ongoing and completed studies conducted by MetroHealth trauma experts.

Huang JI, Paczas M, Hoyen HA, Vallier HA. Functional outcome after open reduction and internal fixation of intraarticular fractures of the distal humerus in the elderly. Journal of Orthopaedic Trauma, epub ahead of print, April 4, 2011.

Malone KJ, Matuszak S, Greene PW, Mayo DB, The effect of epinephrine lavage on post operative blood loss following total knee arthroplasty. Orthopaedics 2009; 32(2): 100-03.

Gillespie R, Ramachandran V, Lea E, Vallier HA. Biomechanical evaluation of three-part proximal humerus fractures: A cadaveric study. Orthopaedics. 32:1-6, 2009.
Friess DM, Attia A, Vallier HA. Locking plate fixation for fractures of the proximal humerus: A comparison with other techniques, Orthopaedics, 31:1183-1190. 2008.

Kilgore KL, Hoyen HA, Bryden AM, Hart RL, KEITH MW, Peckham PH: An Implanted Upper Extremity Neuroprosthesis Using Myoelectric Control, The Journal of Hand Surgery, 33A(4) 539-550, 2008.

Bryden AM, Kilgore KL, Keith MW, Peckham PH: Assessing activity of daily living performance after implantation of an upper extremity neuroprosthesis, Top Spinal Cord Inj Rehabil, 13(4):37-53, 2008.

Martineau PA, Waitayawinyu T, Malone KJ, Hanel DP, Trumble TE. Volar Plating of 4 Part Intraarticular Distal Radius Fractures: Biomechanical Evaluation of Locking Screw and Locking Smooth Peg Configurations. J Hand Surg 2008; 33(6): 827-34.

Polasek K, Hoyen HA, Keith MW, Tyler DJ: Nerve Thresholds and Selective Activation in the Human with the Spiral Nerve Cuff Electrode. IEEE Trans Neural Eng and Rehab, 15(1): 76, 2007.

Bales CP, Placzek JD, Malone KJ, Vaulpel Z, Arnoczky SP, Microvascular supply of the lateral epicondyle and common extensor origin. J Shoulder Elbow Surg 2007; 16: 497-501.

Huang JI, Toogood P, Chen MR, Wilber JH, Cooperman DR: Clavicular Anatomy and the Applicability of Precontoured Plates. The Journal of Bone and Joint Surgery Am., 89A:2260-2265, 2007.

Vallier HA. State of the Art: Treatment of Proximal Humerus Fractures. Journal of Orthopaedic Trauma, 21:469-476, 2007.