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Gastroenterology Research Trials

The gastroenterology team at MetroHealth is devoted to ongoing research. Our clinicians know that the research we do benefits patients both now and in the future. As a result, we have many research trials underway at any given time. 

Correlation Between Elevated Fat Mass and Prevalence of GERD Symptoms

Study Aim: To correlate the prevalence of GERD (gastroesophageal reflux disease) symptoms and the level of esophageal mucosal injury with increased fat-free mass assessed by bioelectric impedance analysis (BIA), body mass index (BMI) and anthropometry.

To be included in this study, patients must:

  • Be between ages 18 and 75
  • Have BMI scores from 18 to 60
  • Experience GERD symptoms at least twice weekly for the past three months while on PPI
  • Be undergoing clinically indicated EGD (upper endoscopy)

Ironwood: A Phase 2a Study to Evaluate the Effect of IW-3718 Administered Orally for Four Weeks in Patients with GERD Not Completely Responsive to Proton Pump Inhibitors

Study Aim: To test the safety and effectiveness of the study drug IW-3718 (same active ingredient of Whelcol) in subjects with GERD who still have symptoms even while treated with once-daily PPIs.

To be included in this study, patients must:

  • Be age 18 to 65
  • Have a confirmed diagnosis of GERD
  • Reports persistent symptoms (heartburn or acid regurgitation)
  • Have an eight-week or longer history of PPI once-daily treatment

Primary investigator: Ronnie Fass, MD.