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Do You Have Diabetes?


Help to determine the best long-term treatment for people with diabetes

Quick Facts about the GRADE Study   

[Download GRADE brochure here]

The National Institute of Health is conducting the GRADE Study (The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) to determine the best combination drug treatment for type 2 diabetes.

People who take part will all take metformin and will be randomly assigned (like a coin flip) to take one additional diabetes drug. The medicines and medication combinations used in GRADE are FDA-approved and recommended by the American Diabetes Association.

Diabetes medications, visits, and lab tests will be provided free of charge. Visits will be scheduled every 3 months for up to 7 years.

What are we doing in the study?

Most people with diabetes need drugs to help control blood sugar. Metformin is the usual first-line drug treatment for diabetes. Eventually, most people treated with metformin need a second drug. The American Diabetes Association recommends 4 potential second-line treatments for people who need two drugs. It is not clear which of the four is best for controlling diabetes over the long term when combined with metformin.

The goal of the GRADE Study is to try to answer this question.

Visit https://grade.bsc.gwu.edu, to learn more about the study.

Can I be included in this study?

Yes, if you are:
❚ An adult with diabetes for less than
10 years
❚ Only taking metformin for your diabetes
or willing to start metformin
❚ Are willing to take a second diabetes
❚ Speak and read in English
❚ HbA1c between 6.8 and 8.5%

No, if you:
❚ Have had weight loss surgery
❚ Have advanced heart or kidney disease
❚ Are already taking 2 diabetes
medications, or have taken 2
medications in the last 6 months
❚ Are currently pregnant or breastfeeding
or plan to become pregnant in the next
4-7 years.

For more information about what the study involves, download our brochure by clicking here.

Contact Us!

Cindy Newman 216-778-3237 or Gloria McPhee 216-778-5199


© Copyright 2002 - The MetroHealth System|2500 MetroHealth Drive|Cleveland, OH 44109|(216) 778-7800|All Rights Reserved.
  • © Copyright 2002 - The MetroHealth System
  • 2500 MetroHealth Drive|Cleveland, OH 44109|(216) 778-7800
  • All Rights Reserved.